Wolf Killer,
Give a good look at the CZ chambered for .416 Rigby. (If you are considering using the 416 in tropical climates the Rigby case allows for velocities similar to the .416 Remington.....but at lower operating pressures. An important consideration in hot climates!)
Also prior to deciding on a rifle or caliber to be used for hunting dangerous game....here is some information worth reading:
http://www.african-hunter.com/lessons_learned.htm
I would give this information some attention prior to making a decision!
P.S. As the article mentions....even the Ruger # 1 might be an acceptable alternative!
Good luck with your decision...let us know what you decide!