You are kinda asking a handgun to do 2 different things...Kinda like using a driver in a sandtrap...
It would be hard to beat a Ruger Blackhawk .44 Magnum for hunting large game...It's a very versital and reliable hunting round...
This gun could be used for personal defense, or you could go with a Ruger Redhawk for that purpose...But, something like a Glock 23, which is a .40 caliber with a 12 round clip would be a better chioce for personal protection...
There, I've solved your problem...You need to buy two!!!
The wife wouldn't buy a new dress without buying shoes and a pocketbook to go with it would she???