Check to see if the .410 is legal first.
My hunting buddy's daughter has taken 2 or 3 does on our land with the .410. All were killed cleanly, but some tracking was required each time. I think all the ones she shot were shot from a tree stand from 40 yards or less. You really should limit your shots to less than 50 yards and wait for a good broadside shot.
A .410 slug is pretty weak for deer hunting, but if that's all you have available, I would say use it, but keep the shots close, and don't try and shoot thru the shoulders or take an angling shot.
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