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My personal minimum is the 100 grain bullet from a 25 caliber.
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I agree with James B. Though both of us hunt areas where the whitetail and mule deer are larger body types than in the southern areas. Even so I don't think a 22cal has any place in the deer woods and especially not when 300 yards shots may be used!!
As far as bullet I prefer the Nosler Ballistic tip for deer, due to accuracy and longer ranges may be required here on the prairies.