The answer depends on the crossbow and the arrow you are using. There are lots of different broadheads from fixed, to mechanicals that will fly good from a cross bow. You have to experiment with your arrows, their F.O.C. and different broadheads to see what works for you.
People have good luck with Goldtip Laser II arrows and 100gr Slick Trick broadheads Other people use mechanicals with good results and others use Muzzy's with good results.
There is no 'Magical" broadhead that flies perefct with every arrow and/or crossbow!!
With mine I have found that Magnus Snuffers 125's and the Spitfire 125's mechanicals work good for me. But like DaGriz said, you will need to experiment, every setup is different.
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Bowtech Destroyer 350,Elite XLR, Crimson Talon 125's and NAP Bloodrunners also 125 Grim Reapers