Although im not a PB fan .....a milder charge 80gr-90gr and a heavy PB will get it done for sure. There is no need to push them harder since they are softer lead and will expand well at low velocity.
The only PB i use is the 45-300gr Plat and i have no doubt it will kill anything i hunt and do it it very well. IMO the heavier/longer PBs have enough sectional density to make up for most other issues. Just dont push them too hard.
Thanks to MD and a Cabelas sale i have a good stock of the 45-300s because i refuse to pay retail on them.
I shot mine into tough media and they held on to over 220grs and i was pushing them with 100grs of BH209. IMO in an animal they would likely hold a bit more. In a 50cal i would consider a PB over 300gr just to keep that SD high. They actually held up better than a 45-300gr XTP on the same day and on the same media.
As far as energy, that load is easily in the 50A&E area and barking up near 50 Beowulf levels. Either is plenty for deer hit in the kill zone.
How many NA game have been taken by the good old 45/70 with loads from 50-70gr of BP and bullets from 300-405grs?...they nearly wiped out the Buffalo/Bison.