A 2 grain deviation with large conicals is very good. You won't be able to blame bad groups on bullet weight.

Yes on the lube but again, so long as it's good lube, less effect than you might guess.
The other day I shot conicals weighing from 280 grains, 300 grains, and 405 grains in my .41 caliber inline.... 75 grains of Pyro P as propellant for all shots, 3 shot groups with the 300 and 405 grainers, 5 shot group with the 280 grain bullets. At 100 yards the vertical and horizontal spread of all 11 bulelts was 3.8" and 3.1", respectively.