I would hunt region B, just based on the number of trophy animals taken compared to the other regions. Region 70 has a 58% success rate, which is one of the best in those regions for a general tag. i will check out my google earth statmap further if you would like more information.
Given the regions you mentioned I wouldn't recommend any of them. you mentioned region M so why not hunt a little more north in Region Y and hit the bighorns? I live in Region D and wouldn't recommend any trophy mulies in the Southeast. Don't get me wrong they are around but not like other areas in the state. If you are guessing throughout the entire state I would recommend Region G and H for the best Mulies in the state by personal experience.
Best area in wyoming?
