Last fall I took a medium size cow elk at around 75 yards with a Winchester factory load using a 140 gr Accubond out of my .270. She was slightly quartered away and the bullet entered just behind the leg, disintegrated the top of the heart, then broke the front leg on the off side and exited. She went another 40 yards and piled up.
I used factory ammo because the rifle was new just before hunting season and I didn't have time to work up a load. Since then, I have been loading the same bullet at 2950 FPS average which closely approximates the Winchester factory loading.
I also read several forums for information on Accubonds and the vast majority of posters who have taken game with them recommend them.