I have taken deer with the 180 accubond and it always passes thru with nice sized exits from my 06. I would not worry about penetration or bullet failure at 308 velocities.
It sounds like you are happy with the TSXs terminal performance but want better energy downrange. I would take a look at the new 168 grain Nosler E-Tip. It has a .503BC which is about the same as the 180 grain Accubond so it will carry energy downrange like the 180 accubond but can be lauched approx 100 fps faster. With its 95% weight retention I would guess the E-tip would outpenetrate the accubond even though its starting weight is less.