At one time, I used to build up my loads to where I felt pressure signs, just to know. I kinda quit doing that. Figured before long, I will cause in an issue. Some modeling programs claim you are hitting 80K PSI when you have flattened primers and extremely heavy bolt lift.
I kinda have a target number I want to hit when building up a load for a rifle. For example my STW only hits 2950fps with 7828 and 160gr. I know I want to hit 3200. So moved to RL22 and RL25 and hit it with accuracy. Could I go further? Sure I could.